This study investigated the effects of teachers’ experience in the academic performance of students in mathematics (A case study of some selected Secondary Schools in Ifako Ijaye Local Government Area of Lagos State). The study adopted descriptive research design. Study population comprised all the 31 Senior Secondary Schools in the selected two local government areas. A sample of 20 Schools was drawn from the population through the process of simple random sampling technique, made up of 14 schools in Ifako Ijaye , and 6 schools in Ifako Ijaye Local Government Areas. An inventory schedule was the instrument used for data collection. 400 questionnaires, 20 questionnaires per school were administered. 388 (97%) questionnaires were returned. Their responses were analyzed through content analysis. The regression analysis and t-test were used to test hypotheses generated for the study at 0.05 alpha levels. Findings reveal that teachers’ teaching experience has significantly influenced students’ academic performance in Mathematics and English Language as measured by their performance in the SSC examinations and as perceived by the respondents. Schools having more teachers with above 10 years teaching experience achieved better results than schools having more teachers with 10 years and below teaching experience.